Neurofibrillary Tangles in Nondemented Elderly Subjects and Mild Alzheimer Disease
نویسندگان
چکیده
منابع مشابه
Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease.
BACKGROUND The relationship between neuropathological lesions and mild, "preclinical," cognitive impairments of Alzheimer disease is poorly understood. Identification of the lesions that are most closely associated with the earliest symptoms of Alzheimer disease is crucial to the understanding of the disease process and the development of treatment strategies to affect its progression. DESIGN...
متن کاملRegional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease.
BACKGROUND Identification of the neuropathological lesions that are most closely associated with the earliest symptoms of Alzheimer disease (AD) is crucial to the understanding of the disease process and the development of treatment strategies to affect its progress. Do the classical neuropathological lesions of AD precede, follow, or occur in synchrony with the earliest signs of cognitive dete...
متن کاملHippocampal sulcus width and cavities: comparison between patients with Alzheimer disease and nondemented elderly subjects.
BACKGROUND AND PURPOSE The hippocampal fissure is a fetal sulcus that, except for its most medial part (the superficial hippocampal sulcus), is normally obliterated. Hippocampal cavities are residual cysts attributable to lack of hippocampal fissure obliteration. We hypothesized that either hippocampal sulcus enlargement or an increase in number or size of hippocampal cavities could be associat...
متن کاملAlzheimer neurofibrillary tangles contain phosphorylated and hidden neurofilament epitopes.
Three monoclonal antibodies to neurofilaments (RT97, BF10 and 147), two of which also recognised neurofibrillary tangles (RT97 and BF10), have all been shown to be specific for phosphorylated epitopes. Treatment of histological sections with alkaline phosphatase prior to immunostaining resulted in reduction of axonal neurofilament staining with all three whilst the neurofibrillary tangles stain...
متن کاملAccumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles.
The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) negatively regulates intracellular levels of PIP3 and antagonizes the PI3K signaling pathway important for cell survival. The present study determined whether altered distribution of PTEN occurs in Alzheimer's disease (AD) brains. We investigated a possible role for PTEN in postmortem brain tissues from elderly controls and pa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Archives of Neurology
سال: 1999
ISSN: 0003-9942
DOI: 10.1001/archneur.56.6.713